Medical management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4165.2012.03.008
- VernacularTitle:动脉瘤性蛛网膜下腔出血后脑血管痉挛的药物治疗
- Author:
Sheng HE
;
Kaifu KE
- Publication Type:Journal Article
- Keywords:
Vasospasm,Intracranial;
Subarachnoid Hemorrhage;
Intracranial Aneurysm;
Brain Ischemia
- From:
International Journal of Cerebrovascular Diseases
2012;20(3):198-203
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence of cerebral vasospasm (CVS) following aneurysmal subarachnoid hemorrhage is a multi-factor participatory process.Its pathogenic mechanism is complex.The clinical presentation and imaging findings are not consistent.Theoretically,by the measures of blocking calcium channels,inhibiting Rho kinase,removing oxygen free radicals and antagonizing endothelin receptors and other measures can prevent and treat CVS,but the actual clinical effects of various drugs are not satisfactory,especially in the aspects of improving clinical outcomes.The clinical application of the 3H therapy has been limited because of having many potential complications,and the intra-arterial interventional treatment is limited by the technology,equipment,indications,and other factors.Therefore,the prevention and treatment of CVS is still facing many challenges.
