The immediate hemodynamic effects of intercoronary ischemic preconditioning on the coronary perfusion pressure and fractional flow reserve
10.3760/cma.j.issn.1008-6315.2012.04.008
- VernacularTitle:心内缺血预处理对冠状动脉灌注压、血流储备分数的快速影响
- Author:
Fang YUAN
;
Ningfu WANG
;
Wei GAO
;
Jianmin YANG
;
Lei LAI
;
Yun SHEN
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Intercoronary ischemic preconditioning;
Coronary wedge pressure;
Fractional flow reserve;
Collateral circulation
- From:
Clinical Medicine of China
2012;28(4):360-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the immediate hemodynamic effects of the intercoronary ischemic preconditioning on the coronary perfusion pressure.Methods The observational study recruited 17 patients who were hospitalized for stable coronary disease and had severe stenosis lesions (70％ ～ 85％ ) in one or two vessels per coronary angiography.They were randomized into ICPC ( n =8 ) group ( receiving two cycles of 1-min balloon inflation and 5-min reperfusion) and control group (n =9).Before interventional treatment,the ICPC group was given 2 cycles of intercomary ischemic preconditioning.The occlusive and non-occlusive pressures proximal and distal to the stenosis were collected before and after ICPC.Fractional flow reserve (FFR) was calculated upon the following equation:FFR =Pd/Pa ( Pa:hyperemic mean aortic pressure,Pd:hyperemic coronary pressure distal to the stenosis).Results Before and after ischemic preconditioning,coronary wedge pressure and FFR of ICPC group were significantly increased ( coronary wedge pressure was from [ 22.08 ± 19.14 ]mm Hg to [25.46 ±19.04]mm Hg,P=0.011;FFR.was from [70.30±16.05]％ to [77.53 ±13.42]％,P=0.001).The collateral flow was increased significantly.Coronary wedge pressure and FFR of control group did not improved obviously.There were significant differences in FFRs and coronary wedge pressures between ICPC and control groups.Conclusion Coronary ischemic preconditioning can improve coronary perfusion pressure,and rapidly increase the coronary pressure distal to the severe stenosis lesions.
