Dual roles of autophagy in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2012.03.016
- VernacularTitle:自噬在脑缺血中的双重作用
- Author:
Yanmei WANG
;
En XU
- Publication Type:Journal Article
- Keywords:
Autophagy;
Brain ischemia;
Ischemic preconditioning;
Neurons;
Cell death;
Apoptosis;
Neuroprotective agents
- From:
International Journal of Cerebrovascular Diseases
2012;20(3):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a degradation process of intracellular composition.It can be divided into four different stages,including initiation,elongation,maturation and autophagosome breakdown.Its role is associated with the degree of cell damage.Moderate activation of autophagy in the case of starvation and hypoxia can promote cell survival; whereas excessive activation during cerebral ischemia can cause cell lysis and promote cell death.Preconditioning may produce ischemic tolerance by appropriate activation of autophagy.Autophagy is strictly regulated by a variety of protein kinases,apoptotic molecules and oxidative stress pathways.
