Correlation between lysyl oxidase-like protein 2 and neoplasms and its mechanism
10.3760/cma.j.issn.1673-422X.2012.04.002
- VernacularTitle:赖氨酰氧化酶样蛋白2与肿瘤的相关性及作用机制
- Author:
Fenping WU
;
Zhixiong YANG
- Publication Type:Journal Article
- Keywords:
Protein-lysine 6-oxidase;
Neoplasms;
Lysyl oxidase-like protein 2
- From:
Journal of International Oncology
2012;39(4):246-248
- CountryChina
- Language:Chinese
-
Abstract:
Lysyl oxidase-like protein 2 (LOXL2) is one of the lysyl oxidases (LOX) families.At present,most of scholars consider that LOXL2 is a neoplasm metastasis gene,whereas some others belleve that LOXL2 is a neoplasm suppressor gene.Studies found that LOXL2 gene combined with other oncogenes promotes neoplasm invasion,metastasis and indicates a poor prognosis.Related researches provide new ideas for judging tumor metastasis and prognosis and looking for new targets for cancer therapy.
