Observation on the effect of lamotrigine combined with depakine in the treatment of traumatic epilepsy recurrence
10.3760/cma.j.issn.1008-6706.2012.03.005
- VernacularTitle:拉莫三嗪联合丙戊酸钠治疗外伤性癫癎复发疗效观察
- Author:
Jinfang ZHOU
;
Lei SHI
;
Shuguang HANG
;
Jian YANG
;
Tianhong PAN
- Publication Type:Journal Article
- Keywords:
Lamotrigine;
Carbamazepine;
Epilepsy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(3):329-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of depakine in the treatment of traumatic epilepsy relapse,and compared carbamazepine and lamotrigine combined with depakine in the treatment of traumatic epilepsy.Methods Open trial in 131 patients with traumatic epilepsy relapse treated with depakine,and all patients were aderministered with carbamazepine or lamotrigine combined with depakine.3 months before treatment,the epilepsy seizures frequency was compared,and 6 months after the treatment,the efficacy,adverse reactions and safety was compared between two mothods.Results Application of carbamazepine or lamotrigine combined with depakine treatment for 6 months,the seizure frequency significantly decreased compared with before treatment;The seizure frequency reduction( ≥50％ ) were 72.6％ and 91.3％,the difference was statistically significant between before and after treatment( P ＜ 0.01 ) ;The adverse reactions of carbamazepine combined with depakine was 37.1％,and it of lamotrigine combined with depakine was 8.7％.Conclusion Lamotrigine combined with depakine in the treatment of traumatic epilepsy recurrence was effective,and its side effects was light.
