The clinical recent effects of two neoadjuvant chemotherapies in the treatment of advanced gastric cancer
10.3760/cma.j.issn.1008-6706.2012.03.009
- VernacularTitle:两种新辅助化疗方案治疗进展期胃癌的近期疗效比较
- Author:
Wei WU
;
Zhiqiang ZHONG
;
Zhujia ZHENG
;
Ying ZHANG
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Antineoplastic combined chemotherapy protocols;
Docetaxel;
Oxaliplatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(3):337-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the recent effects and toxicity in advanced gastric carcinoma by two kinds of neoadjuvant chemotherapies ( PF and FOLFOX).Methods A total of 60 patients with advanced gastric cancer ( Ⅲ ～ Ⅳ ),they were randomly divided into 2 groups; PF group ( 30 cases) and FOLFOX group ( 30 cases).All patients were given 3 cycles of docetaxel or L-OHP chemotherapy preoperatively,to observe the recent effects and toxicity in advanced gastric carcinoma.Results The total effective rate in PF group was 77.67％,while it was 50.00％ in FOLFOX group,it had significant difference between in two groups ( x2 =4.59,P ＜ 0.05 ).There is no difference in the incidence of neutropenia,transaminase elevation,nausea and diarrhea two groups.The incidence of hair loss in PF group is higher than in FOLFOX group,but there is no difference between two groups; The incidence of peripheral nerve paresthesia in FOLFOX group is higher than that in PF group( x2 =5.08,P ＜0.05).Conclusion PF as neoadjuvant chemotherapy is a very effective and well-tolerated regimen in patients with advanced gastric cancer.
