Analysis of the relationship between mycoplasma pneumoniae infection and children asthma
10.3760/cma.j.issn.1008-6706.2012.03.025
- VernacularTitle:肺炎支原体感染与儿童哮喘的相关分析
- Author:
Yueming JIANG
;
Yanqing TU
;
Wei MO
;
Zhiqin LIAO
- Publication Type:Journal Article
- Keywords:
Pneumoniae,mycoplasma;
Asthma;
Children;
Azithromycin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(3):371-373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between mycoplasma pneumoniae(MP) infection and children asthma,and to observe the treatment effects of macrolide antibiotics (azithromycin) on mycoplasma pneumoniae infection.Methods 250 children of respiratory disease were investigated with olimpus electron gastroscope,200 children asthma;the serum specific antibodies were determined by Diagnostic Kit for measurement of antibodies to mycoplasma pneumoniae (Passive Particle Agglutination) ;and the eosinophilic grannlocytes were serologically analyzed in children with recent asthma.Random selection 42 MP infection positive to macrolides antibiotics (azithromycin) treatment.Results 44 MP infection positive,200 children asthma cases had MP infection with 21％ (42/200) MP positive,the specific antibody titers to MP showed significant difference in children with recent asthma compared with those in the contol group ( x2 =6.14,P ＜ 0.05 ),and correlated with the count of eosinophilic granulocy positively ( r =0.603,P ＜ 0.05) ;The positive rates of specific antibody,infection with MP were significantly higher than those in the control group( t =4.38,P ＜ 0.05 ).MP infection positive group with azithromycin treatment effect is significantly higher than that of cefuroxime group ( x2 =16.18,P ＜ 0.05 ).Conclusion MP infection is closely associated with the pathogenesis of children asthma;and early routine testing for MP antibodies.Macrolides antibiotics can eliminate MP infection,a new generation of macrolides antibiotics(azithromycin) is more advantageous to the control of acute attack of asthma.
