Compare the effects of daunorubicin,idarubicin and mitoxantrone in treatment patients with ALM

VernacularTitle:两种诱导化疗方案治疗急性髓系白血病的疗效比较
Author: Yanhong LI
Publication Type:Journal Article
Keywords: Antineoplastic combined chemotherapy protocols; Leukemia myeloid; Endothelial growth factors
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(3):376-378
CountryChina
Language:Chinese
Abstract: Objective To compare the effects of two different chemotherapies in treatment acute myeloid leukemia(ALM) patients.Methods sVEGF concentration was measured by ELISA in 32 AML patients.Section one,15 patients,combined with Ara-C,daunorubicin,etoposide and intrathecal Ara-C.Section two,17 patients,consisted of a combination of Ara-C,idarubicin,etoposide,mitoxantrone and intrathecal Ara-C.Results sVEGF level was significantly increased in newly diagnosed AML.The level of sVEGF in AML after 2 cycles of standard chemotherapy was significantly lower than newly diagnosed cases,but the effect of section two was much better compared with section one.Compared with the section one,the complete remission rate of section 2 was 82.4％ (P ＜ 0.05 ).Conclusion sVEGF as a proangiogenesis factor was significantly increased in serum with AML.The level of sVEGF in patients with AML obtained thermotherapy was significantly lower than that of pre-treating AML ones.VEGF should play a very important role in the leukemogenic process.The section two therapy should be used clinically.