The role of connective tissue growth factor in bone metabolism
10.3760/cma.j.issn.1000-6699.2012.03.023
- VernacularTitle:结缔组织生长因子在骨代谢中的作用
- Author:
Min WU
;
Yiqun PENG
;
Eryuan LIAO
- Publication Type:Journal Article
- Keywords:
Connective tissue growth factor;
Osteoblasts;
Osteoclasts;
Chondrocytes;
Angiogenesis
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(3):249-251
- CountryChina
- Language:Chinese
-
Abstract:
It has been demonstrated that connective tissue growth factor(CTGF) may enhance proliferation and differentiation of osteoblasts,inhibit the functions of osteoblasts,increase osteoclastogenesis in patients with Rheumatoid Arthritis,stimulate proliferation and differentiation of chondrocytes,and induce angiogenesis in vivo and vitro.Above all,CTGF plays an important role in sustaining growth of skeleton and cartilage,and thus maintaining bone quantity.
