Advances in research on Wnt/β-catenin pathway in hepatic oval cell activation and proliferation
10.3760/cma.i.issn.1007-8118.2012.03.022
- VernacularTitle:肝卵圆细胞激活和增殖过程中Wnt/β-catenin通路的研究进展
- Author:
Qing HUANG
;
Xingyuan JIAO
;
Yize HU
- Publication Type:Journal Article
- Keywords:
Liver;
Stem cell;
Oval cell;
Wnt/β-catenin pathway
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(3):235-238
- CountryChina
- Language:Chinese
-
Abstract:
End stage liver disease is a serious threat to human health.Existing conventional therapies are far from ideal,and orthotopic liver transplantation is limited by the lack of donor liver.A new therapy,transplantation of hepatic stem cell,is a promising approach.Hepatic oval cells are hepatic stem/progenitor cells(HSC/HPC)during hepatic regeneration,and they are being referred to as hepatic precursor cells.It got its name because of its oval nucleus,high nuclear/cytoplasmic ratio and other morphological features.Research has shown increasingly importance in the knowledge of hepatic oval cells.There are many signaling pathways in hepatic oval cells activation and proliferation.As a branch of the Wnt signaling pathway,Wnt/β-catenin signaling pathway has a significant effect on hepatic oval cells activation and proliferation.However,the exact mechanisms of this process have not been completely elucidated.This review describes the role of Wnt/β-catenin signaling pathway in hepatic oval cell activation and proliferation.
