Comparison of the effects of fenofibrate and polyene phosphatidylcholine in the treatment of non-alcoholic fatty liver disease

VernacularTitle:非诺贝特与多烯磷脂酰胆碱治疗非酒精性脂肪肝效果比较
Author: Keqing HUANG ; Xiaohui ZHENG ; Guangli WANG ; Jianqi ZHUANG
Publication Type:Journal Article
Keywords: Fenofibrate; Non-alcoholic fatty liver
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(3):325-326
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical effects of fenofibrate and polyene phosphatidylcholine in treatment of non-alcoholic fatty liver disease.Methods 86 patients with non-alcoholic fatty liver disease were randomly divided into two groups.45 cases in therapy group received 0.2g of fenofibrate once a day,and the others in control group received 456mg of polyene phosphatidylcholine for three times per day.All of the patients were treated for 12 weeks.Liver function,blood fat,clinical effect and liver B ultrasonic were analyzed before treatment and after 12 weeks.Results The improvement of liver function,blood fat,and liver ultrasonic imaging in therapy group was better than that in the control group.The cure rate was 82.2％ in therapy group and 63.4％ in control group.There was a statistical significance between the two groups ( x2 =3.874,P ＜ 0.05).Conclusion Fenofibrate had significant therapeutic effect in treatment of non-alcoholic fatty liver disease with lower costs and lower side effects.