Detection of food allergen-specific IgE and IgG in patients with chronic urticaria

VernacularTitle:慢性荨麻疹患者食物过敏原特异性IgE及IgG检测
Author: Junfang ZHAO ; Guizhen LI ; Hongli ZHAO ; Mengjuan LI
Publication Type:Journal Article
From: Chinese Journal of Dermatology 2012;45(3):203-204
CountryChina
Language:Chinese
Abstract: Objective To evaluate the roles of food allergen detection in patients with chronic urticaria.Methods Food allergen-specific IgE and IgG were detected in 502 patients with chronic urticaria and 100 normal human controls.Double-blind,placebo-controlled food challenge (DBPCFC) test was performed in patients who were proved to be positive or negative for food-specific IgG or IgE.Results Food-specific IgE was detected in 37.45％ (188/502) of the patients,with cashew,peanuts and soybeans as the most common allergens.The detection rate of food-specific IgG was 72.11％ (361/502),with the major allergens being milk,egg,shrimp and crab.DBPCFC revealed false positivity and negativity in the detection of food-specific IgG and IgE.Conclusions Clinicians should pay attention to food allergen detection in the treatment of chronic urticaria,especially in the treatment of allergy mediated by IgG antibodies.