Study on renal perfusion of patients with liver cirrhosis by contrast-enhanced ultrasound
10.3760/cma.j.issn.1004-4477.2012.03.011
- VernacularTitle:肝硬化患者肾血流灌注的超声造影研究
- Author:
Jian WANG
;
Chunsong KANG
;
Kailing SHI
;
Jiping XUE
;
Ruili WANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Liver cirrhosis;
Renal circulation
- From:
Chinese Journal of Ultrasonography
2012;21(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the renal perfusion of different severity of hepatic cirrhosis by contrast-enhanced ultrasound with time-intensity curve.Methods Forty hepatic cirrhosis patients with normal conventional renal function enrolled the study and were subdivided into Child-Pugh A group ( n =14),Child-Pugh B group ( n =14) and Child-Pugh C group ( n =12).Thirty healthy subjects were selected as the control group.The parameters of perfusion were compared among the groups.The correlations between parameters and score of Child-Pugh were analyzed using Pearson correlation.Results The cirrhosis groups showed a decrease of peak intensity,increase of time to peak,and reduce of area under the curve in the renal cortex( P ＜0.05).Compared with Child-Pugh A group,the peak intensity decreased in both ChildPugh B and C groups,time to peak increased in Child-Pugh C group( P ＜0.05 or P ＜0.01 ).The peak intensity had negative correlation with Child-Pugh score( r =- 0.506,P ＜0.01 ).Conclusions Contrastenhanced ultrasound combined with time-intensity curve can assess renal perfusion of hepatic cirrhosis quantitatively.The peak intensity was correlated to the severity of cirrhosis.
