Effect of α1-microglobulin and β2-microglobulin on calcium oxalate urine stone formation
10.3760/cma.j.issn.1000-6702.2012.03.011
- VernacularTitle:尿α1和β2-微球蛋白含量变化在草酸钙结石形成中的作用
- Author:
Yanting LOU
;
Chaozhao LIANG
;
Yifei ZHANG
;
Zongyao HAO
;
Jun ZHOU
- Publication Type:Journal Article
- Keywords:
Urinary calculi;
Stone analysis;
24 h urine analysis;
Electrolytes;
M icroglobulin
- From:
Chinese Journal of Urology
2012;33(3):199-202
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo define the difference of urine analysis result,α1-microglobulin (α1-MG) and β2-microglobulin ( β2-MG) between those patients suffering from calcium oxalate stone,non-calcium oxalate stone and non-urolithiasis controls at the same time period.MethodsData from 100 patients admitted to the Department of Urology,First Affiliated Hospital of Anhui Medical University from July,2010 to September,2010 were reviewed.66 patients (45 men,21 women) suffered from urolithiasis,and 34 patients (22 men,12 women) were non-urolithiasis.Patients' ages in urolithiasis group varied from 13 to 78 years and the male to female ratio was 2.1∶1.0.The patients in non-urolithiasis controlgroup aged from 12 to 80 years and the male to female ratio was 1.8∶1.0.Blood and urine were taken from the patient the next morning after admission.The biochemistry from blood and 24 h urine were measured by automatic biochemistry analyzer.The α 1-MG and β2-MG content were measured by radioimmunoassay.The stone compositions were analyzed by infrared spectroscopy.ResultsThere was difference in the levels of serum creatinine and blood urea nitrogen among three groups ( P ＜ 0.05).In controls,those with calcium oxalate stone had higher level of urinary α1-MG and β2-MG,but there were no differences in the urinary electrolyte levels.Group of non-calcium oxalate stones urinary uric acid levels were higher than calcium oxalate and control groups,the difference was statistically significant.ConclusionsIn the formation of uric acid stones,uric acid increased as independent risk factors.α1-MG,β2-MG may promote the formation of calcium oxalate stones.
