A clinical data analysis of 92 male idiopathic hypogonadotropic hypogonadism patients

VernacularTitle:男性特发性低促性腺激素型性腺功能减退症的诊治分析
Author: Shilin ZHANG ; Tao WANG ; Zhuo LIU ; Ruibao CHEN ; Li ZHUAN ; Shaogang WANG ; Jihong LIU ; Weimin YANG ; Zhangqun YE
Publication Type:Journal Article
Keywords: Idiopathic hypogonadotropic hypogonadism; Kallman syndrome; Gonadorelin
From: Chinese Journal of Urology 2012;33(3):228-231
CountryChina
Language:Chinese
Abstract: ObjectiveTo analyze the clinical features,diagnosis and treatment of male idiopathic hypogonadotropic hypogonadism (IHH).MethodsClinical data of 92 male IHH cases were analyzed retrospectively.ResultsThe mean age at evaluation was 21.0 ± 3.2 yrs,and 52 patients were diagnosed with Kallman syndrome (KS; IHH with anosmia/hyposmia) while the remainder were normosmic IHH (nIHH).All had normal radiological imaging of the hypothalamic and pituitary areas.The level of serum LH,FSH and T was low,and the clinical parameters (development of secondary sexual characteristics,sexual function,and serum testosterone levels.) were significantly improved after hormone replacement therapy.ConclusionsDiagnosis and differential diagnosis of IHH can be clearly defined based on clinical features and laboratory results.Hormone replacement therapy is an effective treatment option.