The effect of metformin on expression of vaspin mRNA in insulin resistant rats induced by high-fat diet
10.3760/cma.j.issn.1000-6699.2012.03.017
- VernacularTitle:二甲双胍对高脂诱导胰岛素抵抗大鼠vaspin mRNA表达水平的影响
- Author:
Huiqiang LIU
;
Lina PEI
;
Jian DU
;
Jing YANG
;
Yingyan ZHANG
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Vaspin;
Metformin;
Euglycemic-hyperinsulinemic clamp;
Rats
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(3):231-234
- CountryChina
- Language:Chinese
-
Abstract:
High-fat diet-induced insulin resistance rat model was assessed by euglycemic-hyperinsulinemic clamp technique.Compared with the control group,the vaspin mRNA expression in adipose tissue was significantly decreased in insulin resistant rats induced by high-fat diet( P＜0.05 ),which was increased by metformin( P＜0.05 ).These data indicate that metformin may ameliorate insulin resistance in rats via upregulating vaspin mRNA expression.
