The protective effects of catalpol on kidney of diabetic rats
10.3760/cma.j.issn.1000-6699.2012.03.019
- VernacularTitle:梓醇对糖尿病大鼠肾脏保护作用及机制探讨
- Author:
Haicheng ZHOU
;
Juan ZHAO
;
Jianling DU
;
Qian XING
;
Junjie YAO
;
Dan LIU
;
Lili MEN
- Publication Type:Journal Article
- Keywords:
Catalpol;
Diabetic nephropathy;
Insulin-like growth factor - I;
Protein kinase B
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(3):237-238
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to explone whether catalpol exerts a protective effects on kidney of diabetic rats and its possible mechanism.Insulin-like growth factor- I ( IGF- I ) and protein kinase B (PKB/Akt)mRNA and protein expression in kidney of diabetic rats were up-regulated as results of assessments by RT-PCR,immunohistochemistry and Western blot.Catalpol could partially reduce IGF- Ⅰ and Akt expressions in kidney of diabetic rats,and thus alleviate the damage of kidney.
