Relationship between a novel polymorphism of C5L2 gene C698T and type 2 diabetes in Uygur population of Xinjiang region
10.3760/cma.j.issn.1000-6699.2012.03.005
- VernacularTitle:C5L2基因新的SNP位点C698T与新疆地区维吾尔族人群2型糖尿病的相关性研究
- Author:
Yingying ZHENG
;
Zhenyan FU
;
Yitong MA
;
Xiang XIE
;
Yining YANG
;
Xiaomei LI
;
Sijin YANG
;
Fen LIU
;
Bangdang CHEN
- Publication Type:Journal Article
- Keywords:
C5L2 gene;
Acylation-stimulating protein;
Diabetes mellitus,type 2;
Uygur
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(3):186-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between a novel polymorphism of C5L2 gene and type 2 diabetes mellitus (T2DM) in Uygur population from Xinjiang region.Methods A novel single nucleotide polymorphism(SNP),698C＞T(P233L) was found using a polymerase chain reaction direct-sequencing method.C5L2 gene 698C ＞ T variant from 252 patients with T2DM and 747 healthy control subjects was detected by polymerase chain reaction and restriction fragment length polymorphism.Result Heterozygote carriers of the 698CT genotype were more frequent among T2DM patients than that among controls (0.107 vs 0.036,x2 =18.576,P＜0.01) in the Uygur population. After adjustment of confounding factors such as sex,age,smoking,alcohol consumption,and hypertension,as well as serum levels of triglyceride,total cholesterol,low-density lipoproteincholesterol,and high-density lipoprotein-cholesterol,the difference remained significant ( P＜0.01,OR =3.373,95％ CI 1.736-6.553 ).Conclusion The CT genotype of the C5L2 gene might be a risk factor of T2DM in Uygur nationality population in Xinjiang.
