On the expression of cytokine in monocyte by intermittent high glucose
10.3760/cma.j.issn.1000-6699.2012.03.020
- VernacularTitle:高糖波动对单核细胞表达细胞因子的影响及机制
- Author:
Wei YOU
;
Jiazhong SUN
;
Yanlei SUN
- Publication Type:Journal Article
- Keywords:
Intermittent high glucose;
Monocyte;
Oxidative stress;
NF-κB
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(3):239-241
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of damage in monocytes with the oxidation inhibitor α-lipoic acid (ALA) was observed under intermittent high glucose condition.The results showed that fluctuating high blood glucose levels led to more damage than that under constant high blood glucose level in monocyte,and antioxidant α-ALA could ameliorate the oxidative stress.The high level of nuclear factor-κB and monocyte chemotactic protein-1 are probably among the factors that cause vascular damage by deposit of monocytes.
