The role of TSH in cholesterol synthesis
10.3760/cma.j.issn.1000-6699.2012.03.002
- VernacularTitle:TSH在胆固醇合成中的作用
- Author:
Limin TIAN
;
Ling GAO
;
Jiajun ZHAO
- Publication Type:Journal Article
- Keywords:
TSH;
Liver cells;
HMG-CoA reductase;
Total cholesterol
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(3):175-177
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid diseases are often accompanied with dyslipidemia.In me past,low level of myroid hormone(TH) was considered a main factor in causing elevated level of blood cholesterol in hypothyroid patients.However,some clinical features can not be explained by this traditional theory. For example,in subclinical hypothyroid cases,both levels of thyroid-stimulating hormone (TSH) and serum total cholesterol (TC) increase,while TH level remains normal.From this phenomenon,we speculate that in case with hypothyroidism,not only there is a relationship between serum TC and TH levels,but also serum TC level change is related to TSH in some way,which has not been noticed.The purpose of this paper is to review the new and most advanced progress in the research of TSH and cholesterol.
