Simulation analysis of optic nerve stimulation with penetrating electrode
10.3760/cma.j.issn.1673-4181.2012.01.007
- VernacularTitle:刺入式电极刺激视神经的仿真研究
- Author:
Fang LUO
;
Qingli QIAO
;
Hongwei GUO
;
Zhen WANG
- Publication Type:Journal Article
- Keywords:
Penetrating electrode;
Optic nerve;
Excitation threshold;
Activation function
- From:
International Journal of Biomedical Engineering
2012;35(1):24-28
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveOptic nerve stimulation with penetrating electrode.is a new method for developing visual prosthesis.A simulation system was developed with computer software MATLAB to investigate its mechanism.MethodsVolume conductor model of optic nerve and optic nerve fiber model were developed.With the stimulation of monopolar penetrating electrode,the excitation thresholds of fibers at different depth were calculated.The activating function and activation region were employed to characterize the external stimulation effect.The impact of different parameters on stimulation effects were explored by changing the fiber diameter and the stimulation pulse width.Results Excitation thresholds increased as well as the percentage of activated fibers with the increase of electrode-fiber distance.Excitation threshold of the same depth fiber decreased as the fiber diameter increased,and the longer the electrode-fiber distance was,the more significant the drop was.Excitation threshold of the same depth fiber decreased as the pulse width of monophasic rectangle wave increased.The excitation threshold of the fiber at the same depth hardly changed for pulse durations greater than 0.5 ms.ConclusionThe simulation results indicates that optical nerve stimulation can be realized with penetratingelectrode,and different stimulation parameters can produce different activation effects.The present results providetheoretical guidance for the design of experiments.
