The expression of Twist protein in adenocarcinoma of prostate and its relationship with prognosis

VernacularTitle:Twist蛋白在前列腺癌组织中的表达及预后关系
Author: Zhengwen XIONG ; Qingfeng WANG ; Wei LI ; Yong HUANG ; Xiaodong NIU
Publication Type:Journal Article
Keywords: Twist transcription factor/ME; Prostatic neoplasms/ME; Prognosis
From: Journal of Chinese Physician 2012;14(2):170-172
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the expression of Twist protein in adenocarcinoma of prostate and clinicopathological features and explore its roles in the carcinogenesis and progression of adenocarcinoma of prostate and its relationship with prognosis.MethodsThe expression of Twist was detected in 70 cases with adenocarcinoma of prostate and 30 cases with side cancer tissue by immunohistochemistry (EnlivionTM).ResultsThe expression of Twist protein in adenocarcinoma of prostate was higher than side cancer tissue.The expression of twist was related to Gleason grade,clinical stage and bony metastasis (P＜0.05),but it was not related to the age (P＞0.05).The survival rate of Twist protein positive patients was significant lower than negative patients(x2=9.52,P＜0.01).ConclusionsTwist might be an important biological marker for malignant transformation and invasion and metastasis adenocarcinoma of prostate,and the up-regulation of the expression of Twist reflects more invasion and poor prognosis.