Application of different priming dose of muscle relaxant in endotracheal intubation and general anesthesia
10.3760/cma.j.issn.1008-1372.2012.02.012
- VernacularTitle:预注肌松药在全身麻醉下气管内插管术的应用
- Author:
Zhonghua JI
;
Ruidong QIAO
;
Hao WANG
;
Xihong FAN
- Publication Type:Journal Article
- Keywords:
Neuromuscular nondepolarizing agents/AD;
Anesthesia,general;
Intubation,intratracheal
- From:
Journal of Chinese Physician
2012;14(2):185-187
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effects of different priming dose of muscle relaxant at the onset and endotracheal intubation conditions.Methods120 ASA Ⅰ～Ⅱ grade patients were randomly divided into 6 groups (n=6),vecuronium group (V 1,V2,V3) and cis-atrscurium group (C1,C2,C3).All patients were induced with propofol plasma (TCI)3 μg/ml,fentanil3 μg/kg.The V1 and C1 group were not given priming dose,and the V2,V3,C2,C3 groups were given priming dose of 10 μg/kg,20 μg/kg vecuronium and 15 μg/kg,30 μg/kg cis-atracurium.Intubating conditions were evaluated,and the onset time was monitored with train-of-four (TOF) technique.ResultsIntubating conditions were excellent in all patients.The onset time of priming groups of the four different doses was significantly shorter than that of the nonpriming group [(80.5±7.2) vs (146±10.7);(79.8±6.5) vs (146±10.7);(138.5±7.2) vs (218±10.7) ; (127.1±6.5) vs (218±10.7),P ＜ 0.05 ].ConclusionsThe taking-effect time of priming dose of muscle relaxant was significantly shorter than that of the nonpriming dose group.Increasing the priming dose not decrease onset time more than the smaller dose.
