The clinical observation of neoadjuvant chemotherapy with TAC scheme in breast cancer
10.3760/cma.j.issn.1008-6706.2012.02.003
- VernacularTitle:TAC方案用于乳腺癌新辅助化疗的疗效观察
- Author:
Wenli GUO
;
Qixia YU
;
Gaiping CHEN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Chemotherapy,adjuvant
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(2):167-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical effects of neoadjuvant chemotherapy of TAC scheme in breast cancer.Methods 82 patients with locally advanced breast cancer receiving neoadjuvant TAC chemotherapy program were retrospectively analyzed.The total efficiency,toxicity,and recent surgical cases were evaluated.Results There were 21 cases of CR in 82 cases with breast cancer,accounting for 25.6％,47 PR(57.3 ％),14 SD(17.1％),so the clinical total effective rate was 82.9％.The major toxic reactions was bone marrow suppression and neutropenia occurrence rate was 81.7％.Other adverse effects include gastrointestinal symptoms and liver dysfunction,and alopecia.All patients after symptomatic treatment can be tolerated.Conclusion TAC program neoadjuvant chemotherapy for locally advanced breast cancer patients can improve the cure rate,increase breast-conserving opportunities.
