Clinical Value of serum CA125 ,CA72-4 and TSGF in ovarian cancer
10.3760/cma.j.issn.1008-6706.2012.02.006
- VernacularTitle:联合检测卵巢癌患者血清CA125、CA72-4和肿瘤特异性生长因子的价值
- Author:
Zhenhua QIU
;
Zihui QI
;
Yunhua SHU
;
Kai WEI
- Publication Type:Journal Article
- Keywords:
Ovary neoplasms;
Carbohydrate antigen;
Tumor specific growth factor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(2):173-175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of combined detection of the serum levels of CA125,CA72-4 and tumor specific growth factor(TSGF)in the diagnosis of ovary cancer and the curative effect.Methods Serum levels of CA125,CA72-4 and TSGF in 68 patients with ovary cancer,53 patients with benign ovary rumor and 50 normal controls were measured by chemiluminescent immunoassay(CLIA)and chemical colorimetry.Results and clinical data were statisticaly analyzed.Results The levels of CA125,CA72-4 and TSGF in ovary cancer group were higher than that in the benign ovarian tumor group and healthy controls(all P ＜0.01).When use three tumor markers united detection,sensitivity,specificity and accuracy were 91.2％,83.0％ and 87.4％ respectively.The sensitivity and accuracy was higher than any single detection.The specificity with single CA125 testing was consistently.The levels of CA125,CA72-4 and TSGF in patients with ovary cancer were significantly different after surgical treatment for five days(all P ＜0.05).Conclusion The combined detection of the three markers may increase the positive rate in the early diagnosis of ovarian cancer,and help to differentiate the benign and malignant ovarian tumor,but also is valuable to observe the curative rate and postoperative monitor of the ovary cancer.
