Changes of serum GP73 after hepatectomy and its relationship with recurrence in hepatocellular carcinoma patients
10.3760/cma.j.issn.1007-631X.2012.02.008
- VernacularTitle:肝切除术后血清高尔基体蛋白73的变化与肝癌复发的关系
- Author:
Huayu YANG
;
Yongliang SUN
;
Yilei MAO
;
Haifeng XU
;
Jinchun ZHANG
;
Xin LU
;
Xinting SANG
;
Shouxian ZHONG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Neoplasm proteins;
Neoplasm recurrence,local;
Golgi membrane protein 73,GP73;
Prognosis
- From:
Chinese Journal of General Surgery
2012;27(2):115-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate changes of GP73 after hepatectomy and its correlations with hepatocellular carcinoma (HCC) recurrence. Methods Perioperative serum GP73 was monitored in hepatic hemangioma and HCC patients undergoing hepatectomy. Clinicopathologic features and follow-up results were collected to evaluate the relationship between serum GP73 level and patients' prognosis.Results There was no statistical difference between preoperative GP73 and postoperative GP73 in hepatic hemangioma group.While preoperative GP73 in HCC group was 9.9(3.7 - 15.8) relative unit (RU),and that on POD3 (postoperative day 3 ) was 9.1 ( 3.4 - 13.3 ) RU,on POD7 was 74.3 ( 1.7 - 9.0) RU,on POD14 was 3.3(2.1 -5.4) RU ( F =72.606,P ＜ 0.001 ).HCC recurred in 21 cases during follow-up,GP73 in recurrent cases [ 11.0 (8.4 - 13.8 ) RU ] was significantly higher than postoperative trough values while it was not different from their preoperative GP73 level [ 9.9 ( 2.9 - 15.0) RU ] ( Z =1.185,P ＞0.05). The preoperative GP73 level between recurrent subgroup and nonrecurrent subgroup was not significantly different (Z =- 1.546,P ＞ 0.05 ).Preoperative GP73 did not correlate to patients' survival.Conclusions Hepatectomy for HCC leads to a significant decrease of GP73 and postoperative HCC recurrence accompanies reelevation of GP73. GP73 could be used as a postoperative monitor for HCC recurrence.
