Progress in the research on tumor drug-resistance mediated by cancer physical microenvironment
10.3760/cma.j.issn.1673-4181.2012.01.014
- VernacularTitle:肿瘤物理微环境介导肿瘤耐药性研究进展
- Author:
Huagen LI
;
Yuan LI
- Publication Type:Journal Article
- Keywords:
Cancer;
Physical microenvironment;
Drug resistance
- From:
International Journal of Biomedical Engineering
2012;35(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
Anticancer drugs resistance is often ascribed to gene mutation,amplification or epigenetic changes that affect the uptake,metabolism or export of drugs at the cell level.Tumor physical microenvironment not only influences the drug distribution but also causes difference in cell proliferation rate and hypoxia or acidosis due to its heterogeneity,which could affect the tumor drug resistance.This review discusses the relationship between cancer physical microenvironment and drug resistance and the strategies for enhancement of the chemotherapy sensitivity through modification of the tumor physical microenvironments,as well as foreground of the research.
