Research progress in leucine-rich repeat (in FLⅡ) interacting protein 1

VernacularTitle:富含亮氨酸重复序列的结合蛋白1的研究进展
Author: Zhuchang JIANG ; Junhong SHE
Publication Type:Journal Article
Keywords: Leucine-richrepeat(in FLⅡ)interactingprotein 1; Tumor,Transcription inhibition; Ischemic cerebrovascular disease
From: International Journal of Biomedical Engineering 2012;35(1):61-64
CountryChina
Language:Chinese
Abstract: leucine-rich repeat (in FLⅡ) interacting protein 1(LRRFIP1) is a kind of transcription inhibitory factor which exists in tissue cells of various animals and human body.Its expression increases significantly in epidermal growth,tumors and cerebrovascular diseases.With transcription inhibition feature,it involves in the regulation of signal pathways and the platelet cytoskeleton component.It is also target gene of miRNA regulation and plays an important role in the process.This paper reviews the LRRFIP1 structure characteristics,distribution and function and its regulation mechanism.