A study on CD90, IGF1R expression in hepatocellular carcinoma
10.3760/cma.j.issn.1007-631X.2012.02.012
- VernacularTitle:CD90和胰岛素样生长因子1受体在原发性肝癌中的表达
- Author:
Jian NIU
;
Hewei ZHAO
;
Suwen ZHENG
;
Dongliang YAN
;
Yewei ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Stem cell;
Antigen Thy-1;
Receptor,IGF type 1
- From:Chinese Journal of General Surgery
2012;27(2):131-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CD90,IGF1R in hepatocellular carcinoma.Methods CD90,IGF1R expression were detected by SP immunohistochemical staining in 36 cases of hepatocellular carcinoma,20 cases of normal liver tissue biopsied from patients of chronic cholecystitis undergoing cholecystectomy. Results The positive rate of CD90 (63.89％,23/36),IGF1R (52.78％,19/36) in hepatocellular carcinoma significantly increased (P ＜ 0.05 ); The positive rate of CD90 was higher in UICC Ⅲ - Ⅳ stage group (79.17％ ) than in UICC stage Ⅰ - Ⅱ group (33.33％,P ＜0.05) ;The positive rate of CD90 was higher in low differentiated group (76.92％ ) than in well-differentiated group (56.52％,P ＜0.05).The positive rate of IGF1R was higher in UICC Ⅲ - Ⅳ stage group (70.83％ ) than in UICC stage Ⅰ - Ⅱ group ( 16.67％,P ＜ 0.05 ). The positive rate of IGF1R was higher in low differentiated group (84.62％) than in well-differentiated group (37.38％,P ＜ 0.05 ).The expression of IGF1R was positively correlated with that of CD90 (P ＜ 0.05 ).The median survival of CD90+ patients (85 days) was shorter than CD90- patients ( 505 days ) ( P ＜ 0.05 ).The median survival of IGF1 R + patients (100 days) was shorter than IGF1 R- patients (408 days,P ＜ 0.05). Conclusions CD90 or IGF1R expression correlates positively with the progression of HCC.
