Association of arachidonic acid level in gastric cancer tissue with gender and tumor differentiation
10.3760/cma.j.issn.1674-635X.2012.01.006
- VernacularTitle:胃癌组织中花生四烯酸水平与肿瘤分化程度及性别关系的初步观察
- Author:
Hu SONG
;
Junsheng PENG
;
Chujun LI
;
Jun XIANG
;
Zhonghui LIU
;
Huashe WANG
;
Yanping DU
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Arachidonic acid;
Tissue
- From:
Chinese Journal of Clinical Nutrition
2012;20(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of arachidonic acid (AA) level in gastric cancer (GC) tissue with tumor differentiation and patients' gender.Methods The contents of AA in GC tissue and adjacent matched normal mucosa were measured using gas chromatography/mass spectrometry.The relationships of AA with GC differentiation and patients' gender were analyzed.Results The level of AA significantly decreased in GC tissue (0.190％ ± 0.255 ％) compared with normal tissue (0.274％ ± 0.254％,n =30,P =0.011 ),while the level of AA had no significant difference in the tissues of matched normal mucosa and different TNM stages or among different TNM stages ( all P ＞ 0.05).The AA levels in well and moderately differentiated adenocarcinoma (0.173％ ±0.244％ ) and in poorly differentiated adenocarcinoma (0.195％ ±0.264％) were significantly decreased when compared with those in the paired normal mucosa (0.334％ ± 0.170％,P =0.018; 0.256％ ± 0.275％,P =0.043,respectively),while no significant difference was observed between the different differentiated grades (P =0.895).The level of AA significantly decreased in male patients (0.137％ ± 0.209％ ) as compared with paired normal mucosa (0.275％:± 0.238％,P =0.010),while no positive correlation was observed in female patients as compared with normal group (P=0.477) or in the comparison between male and female groups (P =0.139).Conclusions The AA level remarkably decreases in GC tissue,which may be associated with differentiated grades and patients'gender.In addition,more AA is utilized in male GC patients than female patients.
