Regulatory roles of microRNA in intestinal barrier dysfunction-associated diseases
10.3760/cma.j.issn.1674-635X.2012.01.009
- VernacularTitle:微小RNA调控肠屏障损伤相关炎性疾病的研究进展
- Author:
Yongzhi YANG
;
Yang ZOU
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
MicroRNA;
Intestinal epithelial cell;
Intestinal barrier;
Intestinal inflammation
- From:
Chinese Journal of Clinical Nutrition
2012;20(1):33-38
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a group of small (about 22 nucleotides),endogenous,noncoding RNAs that direct mRNA degradation and translational inhibition post-transcriptionally by binding to complementary sequences in the 3' untranslated regions of specific target mRNAs.miRNAs play multiple important roles in the intestinal epithelium,influencing a number of intestinal disease processes.This review summarizes the regulatory roles of miRNA in intestinal epithelial differentiation,architecture,membrane permeability,immunological function,and more importantly,the intestinal mucosal barrier dysfunction-associated diseases.
