The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension.
10.4093/dmj.2011.35.3.236
- Author:
Ji Hyun KIM
1
;
Su Jin OH
;
Jung Min LEE
;
Eun Gyoung HONG
;
Jae Myung YU
;
Kyung Ah HAN
;
Kyung Wan MIN
;
Hyun Shik SON
;
Sang Ah CHANG
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. sangah@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Angiotensin receptor blocker;
Arterial stiffness;
Diabetes mellitus;
Hypertension
- MeSH:
Angiotensins;
Arterial Pressure;
Blood Glucose;
Cardiovascular Diseases;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Fasting;
Glucose;
Humans;
Hypertension;
Pulse Wave Analysis;
Receptor, Angiotensin, Type 1;
Risk Factors;
Tetrazoles;
Valine;
Vascular Stiffness;
Valsartan
- From:Diabetes & Metabolism Journal
2011;35(3):236-242
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Hypertension and type 2 diabetes mellitus are major risk factors for cardiovascular disease. This study analyzed the changes in central aortic waveforms and pulse wave velocity as well as related parameters after treatment with valsartan, an angiotensin II type 1 receptor blocker, in patients with type 2 diabetes and hypertension. METHODS: We used pulse wave analysis to measure central aortic waveform in a total of 98 subjects. In 47 of these patients, pulse wave velocity measurements were obtained before and after 12 weeks of treatment with valsartan. RESULTS: In the central aortic waveform analysis, the aortic pulse pressure and augmentation index were significantly decreased after valsartan treatment, as was the aortic pulse wave velocity. Factors contributing to the improvement in pulse wave velocity were the fasting blood glucose and haemoglobin A1c levels. CONCLUSION: Short-term treatment with valsartan improves arterial stiffness in patients with type 2 diabetes and hypertension, and the glucose status at baseline was associated with this effect.
