The effects of rosuvastatin on the liver and kidney function and muscle pathology in rats

VernacularTitle:瑞舒伐他汀对大鼠肝肾功能及肌肉的影响
Author: Dongxia LI ; Qing CAO ; Yan ZHOU ; Shuyan CHEN
Publication Type:Journal Article
Keywords: Statins; Side effects
From: Journal of Chinese Physician 2011;02(z2):13-16
CountryChina
Language:Chinese
Abstract: ObjectiveTo study the liver and kidney function and muscle effects of rosuvastatin in rats.MethodsIn this study,twenty healthy male rats (9-month-old) were randomly divided into two groups:normal control group and rosuvastatin treatment group.The first treated group was given conventional feed; The second treated group was given conventional feed and oral rosuvastatin [5mg/( kg · d)] of 12 weeks.The level of liver and kidney function and creatine kinase,histological changes of liver and muscle were examined before and after the treatment.ResultsOur findings demonstrate that the level of liver and kidney function and creatine kinase was no significant difference among the two experimental groups,also no difference before and after treatment( P ＞0.05).At the same time,liver and muscle showed no abnormal pathology.Conclusion These findings collectively indicate that rosuvastatin shows no significant side effects in the liver and kidney function and muscle pathology compared with control group.