Identification of progressive cervical epithelial cell abnormalities using DNA-image-cytometry
- Author:
Nguyen Vu Quoc Huy
- Publication Type:Journal Article
- Keywords:
Cervical epithelial cell abnormalities
- MeSH:
Uterine Cervical Diseases;
Diagnosis;
DNA
- From:Journal of Medical Research
2005;33(1):16-23
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Cohort prospective study was carried out on 196 women with Papanicolaou (Pap) smears diagnosed as ASC, LSIL or AGC. Results: reference standard verification was available in 108 patients. The rate of DNA-aneuploidy in Pap smears increased significantly from cervical intraepithelial neoplasia (CIN) 1 (54%) and CIN2 (64.3%) to CIN3 or above (83.3%) in subsequent biopsies (p<0.05). Using ASC/LSIL/AGC as input cytological criteria and CIN2 or above as output histological diagnosis, positive predictive value (PPV) of conventional cytology and DNA-ICM was 35.2% and 65.9%, respectively (p<0.01). Negative predictive value (NPV) of DNA-ICM was 85.0%. Using CIN3 or above as output histological diagnosis, conventional cytology showed a PPV of 22.2%. PPV and NPV of DNA-ICM were 43.9% and 93.3%, respectively.