Study on recombinant human brain natriuretic peptide in the treatment of heart failure patients with coronary heart disease
10.3760/cma.j.issn.1673-4904.2012.04.007
- VernacularTitle:重组人脑利钠肽对冠心病心力衰竭患者治疗效果的研究
- Author:
Jin CUI
;
Zuofeng JIANG
;
Qiang ZHAO
;
Rongsen MENG
;
Lixia LAO
;
Tongguo WU
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Nitroglycerin;
Natruuretic peptide,brain;
Heart failure
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(4):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of recombinant human brain natriuretic peptide (rhBNP) in the treatment of heart failure patients with coronary heart disease (CHD).Methods Ninety-six CHD patients with heart failure were divided into observation group (48 cases) and control group (48 cases) by random digits table,and rhBNP was used in observation group and nitroglycerin was used in control group.The efficacy,left ventricular ejection fraction (LVEF) and urine output in two groups were observed.Results The total effective rate in observation group was 93.75％ (45/48),and 81.25％ (39/48) in control group,there was significant difference between two groups (P ＜ 0.05).LVEF and urine output after treatment were better than those before treatment [observation group:(57.7 ± 3.9)％ vs. (32.5 ± 3.1 )％,(70.5 ± 31.1 ) ml/h vs.(34.5 ± 13.7) ml/h;control group:(52.2 ± 3.3)％ vs.(33.4 ± 2.9)％,(53.6 ± 23.4) ml/h vs.(33.8 ± 13.4)ml/h,P ＜ 0.05 ].After treatment,LVEF and urine output in observation group were higher than those in control group (P ＜ 0.05 ).Incidence of adverse reaction in observation group was lower than that in control group [ 18.75％ (9/48) vs.35.42％ ( 17/48),P ＜ 0.05 ].Conclusion rhBNP has curative effect and small adverse reactions on CHD patients with heart failure,and can significantly improve the patients' general condition.
