Effect of penehyclidine hydrochloride on serum interleukin-6 and tumor necrosis factor-alpha concentrations following tourniquet deflation in patients undergoing lower limb surgery
10.3760/cma.j.issn.1673-4904.2012.03.001
- VernacularTitle:盐酸戊乙奎醚对下肢手术患者松止血带后血清白细胞介素-6和肿瘤坏死因子-α浓度的影响
- Author:
Zhiqiang ZHOU
;
Ailin LUO
;
Dengwen ZHANG
;
Yeling CHEN
;
Xueren WANG
- Publication Type:Journal Article
- Keywords:
Tourniquets;
Interleukin-6;
Tumor necrosis factor-alpha;
Penehyclidine hydrochloride
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(3):1-3
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of penehyclidine hydrochloride (PHC) on serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α ) concentrations following tourniquet deflation in patients undergoing lower limb surgery.Methods Thirty adult patients,scheduled for unilateral lower limb surgery,ASA classification [ - Ⅱ grades,were divided into control group and research group by random number table,each group of 15 cases.Before anesthesia 30 min,PHC in intravenous infusion of 0.01-0.02 mg/kg in research group,the corresponding volume in intravenous infusion of 0.9% sodium chloride in control group.Peripheral venous blood samples were collected immediately before tourniquet inflation (T0,baseline),immediately before tourniquet deflation(T1),30 min (T2) and 60 min (T3) after tourniquet deflation.Serum IL-6 and TNF- α concentrations were measured by enzyme linked immunosorbentassay.ResaltsSerum TNF- α change at the same time point after tourniquet deflation was not statistically significant between two groups (P ＞ 0.05).Serum IL-6 concentration was decreased at each time point after tourniquet deflation compared with T0 in research group,while increased in control group.Serum IL-6concentration difference of T3 and T0 had statistically significant between research group and control group [ (-8.8 ± 5.6) ng/L vs.( 10.2 ± 6.7) ng/L,P＜ 0.05].ConclusionsPHC in advance can decrease serum IL-6 concentration after tourniquet deflation in patients undergoing lower limb surgery.
