Predictive value on chemotherapeutic sensitivity of the changes of cell cycle and proliferation on locally advanced cervical cancer in the pre-neoadjuvant chemotherapy and post-neoadjuvant chemotherapy
10.3760/cma.j.issn.1673-4904.2012.03.002
- VernacularTitle:局部晚期宫颈癌新辅助化疗前后细胞周期和增殖变化对化疗敏感性预测价值的探讨
- Author:
Hongwen YANG
;
Zhongdong CHEN
;
Bo ZHOU
;
Yongxi QIN
;
Qiang ZHAO
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Cell cycle;
Proliferating cell nuclear antigen;
Neoadjuvant chemotherapy;
Therapeutic evaluation
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(3):3-6
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of neoadjuvant chemotherapy in locally advanced cervical cancer on cell cycle,proliferation,and evaluate the feasibility of proportion of cell in different phase and proliferating cell nuclear antigen(PCNA) as sensitive indices to assess chemotherapeutical sensitivity and therapeutical effect.MethodsForty-nine cases of locally advanced cervical cancer were divided into response group and no-response group according to the clinical efficacy of neoadjuvant chemotherapy.Compared the proportion of cell in different phase and proliferation index of PCNA between two groups.The clinical therapeutic effect was evaluated after 4 weeks in the second neoadjuvant chemotherapy regimen.Results In 49 patients with locally advanced cervical cancer,clinical effective of 39 cases (response group),no effective of 10 cases(no-response group).The S-phase proportion of cell in the pre-neoadjuvant chemotherapy and post-neoadjuvant chemotherapy of response group[ (21.47 ± 5.21 )％ and(18.32 ±5.07)％] were higher than those of no-response group [ (9.63 ± 2.58)％ and ( 10.14 ± 2.32)％ ] (P ＜ 0.05 ).The proliferation index of PCNA of cervical cancer in the pre-neoadjuvant chemotherapy of response group [ ( 81.67 ± 7.14)％ ] was higher than that of no-response group [ (66.99 ± 2.29 )％ ] (P ＜ 0.05 ).Conclusion The S-phase proportion of cell and proliferation index of PCNA in the pre-neoadjuvant chemotherapy are important indexes to assess chemotherapeutical sensitivity and therapeutical effect.
