Experimental study in the effect of various intracranial hypertension upon the cerebral blood flow by transcranial Doppler
10.3760/cma.j.issn.1004-4477.2012.02.021
- VernacularTitle:经颅多普勒对不同程度颅内高压脑血流动力学的实验研究
- Author:
Jingwen WAN
;
Wei KUANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography,Doppler,transcranial;
Intracranial hypertension;
Intracranial pressure;
Brain;
Hemodynamic phenomena
- From:
Chinese Journal of Ultrasonography
2012;21(2):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of transcranial Doppler (TCD) patterns and parameters in various intracranial hypertension.Methods Sixty rabbits were randomized into 3 groups:control group,the group of mild-to-moderate intracranial hypertension,the group of serious intracranial hypertension.Acute intracranial hypertension was induced by inflating the balloon inserted into the epidural space.Blood flow velocity was measured with TCD and intracranial pressure (ICP) as well as cerebral perfusion pressure(CPP) was measured.Mannitol was injected to the animals of intracranial hypertension,blood flow velocity and ICP was measured.ResultsTwo characteristic flow patterns vere observed in the group of mild-to-moderate intracranial hypertension:high resistance pattern,systolic flow.At the last stage of extreme intracranial hypertension in the group of serious intracranial hypertension Doppler sonograms showed three characteristic flow patterns in the following sequence:retrograde diastolic flow,very small systolic flow and zero flow.Multiform retrograde diastolic flows were related to the phases of brain death.Very small systolic flow showed three shapes:systolic-spike,small systolic triangular and small double peak.AftermedicinaltreatmentICPdecreasedinthethegroupofmild-to-moderateintracranial hypertension,blood flow velocity also increased.After the same treatment IC,P and blood flow velocity did not change in the group of serious intracranial hypertension.ConclusionsAnalysing patterns and parameters of TCD may be helpful for evaluating ICP indirectly as well as clinical experience.
