A multicenter study of fracture in patients with rheumatoid arthritis in China
- VernacularTitle:全国多中心类风湿关节炎患者发生骨折的调查研究
- Author:
Lizhi WANG
;
Caihong WANG
;
Xiaofeng LI
;
Xiangcong ZHAO
;
Wenpeng ZHAO
;
Xiuru WANG
;
Yin SU
;
Yuan AN
;
Yunshan ZHOU
;
Ping ZHU
;
Lina CHEN
;
Guochun WANG
;
Xin LU
;
Hongtao JIN
;
Yongfu WANG
;
Rong YANG
;
Zhuoli ZHANG
;
Guangtao LI
;
Xiangyuan LIU
;
Lin SUN
;
Fengxiao ZHANG
;
Jiemei TAO
;
Zhenbin LI
;
Jing YANG
;
Jinying LIN
;
Meiqiu WEI
;
Liufu CUI
;
Rong SHU
;
Xiaomin LIU
;
Dan KE
;
Shaoxian HU
;
Cong YE
;
Xiuyan YANG
;
Hao LI
;
Cibo HUANG
;
Ming GAO
;
Bei LAI
;
Xingfu LI
;
Lijun SONG
;
Zhanguo LI
- Publication Type:Journal Article
- From: Chinese Journal of Rheumatology 2012;16(2):102-106
- CountryChina
- Language:Chinese
- Abstract: ObjectiveTo examine the clinical features of fractures and related risk factors in patients with rheumatoid arthritis(RA) in China.MethodsSix hundred and eighty-one RA patients were randomly selected from department of rheumatology of 18 hospitals of China.Data were obtained from the questionnaire,including age,sex,disease duration,the involvement of joints,treatment regimen,features of fractures etc.The possible risk factors of fracture in patients with RA were analyzed with a multi-variate Logistic regression analysis.Results① In 681 RA patients of the survey,48 patients had 54 fractures,and the incidence of fractures was about 8％.② Fractures occurred at various sites.Foot/ankle,femur,spine and wrist were the mostfrequent sites.③ The Logistic regression analysis showed that several factors increased the risk of fracture in RA patients,including long disease duration (OR:1.245,95％CI:0.987-1.570,P=0.065),male gender(OR:0.433,95％CI:0.199-0.942,P=0.035),more deformed joints(OR:1.042,95％CI:1.006-1.079,P=0.023),family history of RA (OR:2.201,95％CI:0.984-4.923,P=0.055),and high scores of SF-36(OR:1.017,95％CI:1.002-1.033,P=0.028).④ According to the degree of correlation from strong to weak,the risk factors of fracture were disease duration,SF-36,sex,number of deformed joints and family history of rheumatoid arthritis.ConclusionThe incidence of fracture is high in patients with rheumatoid arthritis.Several factors could increase the risk of fractures in RA patients,including long disease duration,male gender,more deformed joints,and family history of RA.In order to prevent the occurrence of fractures,cautions should be taken to prevent the development of fractures and treat the disease aggressively to suppress the disease activity of RA.