Clinical significance of antinucleosome antibody in patients with lupus nephritis

Wuhong XU; Yuanfang Zou; Xiaodong Guan; Xiang Liang; Kequan Chen

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Clinical significance of antinucleosome antibody in patients with lupus nephritis

VernacularTitle:狼疮肾炎患者血清抗核小体抗体水平检测及其临床意义
Author: Wuhong XU ; Yuanfang ZOU ; Xiaodong GUAN ; Xiang LIANG ; Kequan CHEN
Publication Type:Journal Article
Keywords: Lupus nephritis; Therapy; Antinucleosome antibody
From: Chinese Journal of Postgraduates of Medicine 2012;35(4):26-28
CountryChina
Language:Chinese
Abstract: Objective To analyze the correlation between serum antinucleosome antibody (AnuA) and renal pathological characteristic,disease activity as well as some laboratory tests in patients with lupus nephritis (LN).Methods Serum AnuA levels were detected by enzyme-linked immunosorbant assay in 40 patients with LN (observation group) and 40 healthy people (control group).Renal biopsy was examined in all LN patients.The relationships between serum AnuA level and systemic lupus erythematosus disease activity index (SLEDAI),renal pathohistology,laboratory parameters were analyzed.Results The serum AnuA level in observation group before treatment was significantly higher than that in control group [ ( 110.23 ± 80.48) kU/L vs. ( 10.45 ± 8.20) kU/L,P ＜ 0.05 ].Four cases of renal biopsies were class Ⅱ,8 cases were class m,23 cases were class Ⅳ,and 5 cases were class V.Serum AnuA level had significant difference between each class by Kruskal-Wallis rank sum test (P ＜ 0.05),and serum AnuA level of class Ⅳ was the highest (P ＜ 0.05).Serum AnuA level had positive correlation with SLEDAI,urine protein quantitation and anti-double strands DNA antibody (r =0.462,0.521,0.394,P ＜0.05),negative correlation with complement C3 and C4 levels (r =-0.403,-0.489,P ＜ 0.05 ).Serum AnuA level after treatment [ (32.45 ± 18.31) kU/L] was significantly decreased than that before treatment [(110.23 ± 80.48) kU/L](P＜0.05).Conclusions Serum AnuA level is not only a good index of LN activity,but also reflect renal involvement.That serial measurement of serum AnuA level may provide better clinical strategies for the therapy.