A comparative analysis of three diagnostic criteria for multiple myeloma
10.3760/cma.j.issn.0578-1426.2012.02.011
- VernacularTitle:三种诊断标准对多发性骨髓瘤诊断的对比研究
- Author:
Jin LU
;
Xiaojun HUANG
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Diagnostic criteria;
In situ,hybridization,fluorescence;
Flow cytometry
- From:
Chinese Journal of Internal Medicine
2012;51(2):114-116
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the sensitivity among three diagnostic criteria for multiple myeloma.MethodsA total of 220 patients with multiple myeloma were studied retrospectively to compare thesensitivity, aswellastheirclinicalmanifestations, cellmorphologyinbonemarrowand immunophenotype.Results (1) The sensitivity of domestic diagnostic criterion in 1975 was 79.1％ (174/220) and there were some drawbacks in type identify.The sensitivity of WHO diagnostic criterion in 2001 was 97.3％ (214/220) and the sensitivity of domestic diagnostic criteria in 2011 was 100％. (2) Immunoglobulin level in 12.7％ (28/220) patients was ＜ 30 g/L,plasma cells count in bone marrow in 13.6％ (30/220) was ＜ 10％ ; 2.7％ (6/220) patients had not met the standard in immunity globulin and bone marrow plasma cells count.(3) The immunophenotype was CD38 positive ( 100％ ),restricted light chain (kappa/lambda) and CD19 100％,CD138 (98.2％,216/220) negative.ConclusionsAmong the three diagnostic criteria,the highest was 2011 domestic diagnostic criteria.Comprehensive analysis include clinical manifestations,cell morphology,immunophenotype will contribute to the diagnosis for multiple myeloma.
