The effects of ulinastatin-containing autologous cold blood cardioplegic solution on the cardiac function of infants after open heart surgery
10.3760/cma.j.issn.1008-6315.2012.03.002
- VernacularTitle:含乌司他丁自体冷血心脏停搏液对婴儿心脏直视术后心功能的影响
- Author:
Baoying MENG
;
Qing ZHANG
;
Dingrong SHEN
;
Yunxing TI
;
Xiaolan PAN
;
Chao MA
;
Le PENG
;
Yuanxiang WANG
- Publication Type:Journal Article
- Keywords:
Infant;
Congenictal heart disease;
Ulinastatin;
Autologous blood cardioplegic solution;
Myocardial protection
- From:
Clinical Medicine of China
2012;28(3):228-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ulinastatin-containing autologous cold blood cardioplegic solution on the cardiac function of infants after cardiopulmonary bypass surgery.Methods Sixty infants younger than 10 months old,who underwent ventricular septal defect repair under cardiopulmonary bypass,were randomized into autologous cold blood cardioplegia group (30 patients,Group A)and ulinastatincontaining cold blood cardioplegia group (30 patients,Group B).CI,SI and LCWI were monitored 1 and 6 hours after opening the aorta.The time and rate of cardiac resuscitation,as well as the dependence on the inotropic drugs,were intraoperatively monitored.Results The automatic resuscitation rate in two groups was not siynificantly ( P ＞ 0.05).The time for automatic resuscitation were (34.2 ± 4.7) s and (52.1 ± 6.5 ) s for Group B and Group A,respectively ( P ＜ 0.05 ).The rate of dependence on inotropic drug were 40.0％ (12/30) and 66.7％ (20/30)for Group B and Gro~p A,respectively (P ＜ 0.05).Mter the operation,the CI,SI and LCWI of group B were higher than that of group A ( P ＜0.05 ).Conclusion Ulinastatin-containing autologous cold blood cardioplegic solution is beneficial to the functional cardiac recovery of the infants after heart bypass surgery by protecting the immature myocardium.
