Clinical values of Fuzheng Huayu capsule combined with entecavir in the treatment of hepatitis B-induced liver cirrhosis
10.3760/cma.j.issn.1008-6315.2012.03.007
- VernacularTitle:恩替卡韦联合扶正化淤胶囊治疗乙型肝炎肝纤维化的临床研究
- Author:
Yulan WANG
;
Guoshun ZHANG
;
Guohua TIAN
;
Xiaoping XU
;
Xuejun ZHANG
;
Ning MA
- Publication Type:Journal Article
- Keywords:
Entecavir;
Fuzheng Huayu capsule;
Hepatitis B;
Liver cirhosis
- From:
Clinical Medicine of China
2012;28(3):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of Fuzheng huayu capsule in combination With anti-viral drugs in the treatment of hepatitis B-mediated liver cirrhosis.Methods One hundred and twentysix patients with liver cirrhosis resulting from hepatitis B were randomized into group A (38 cases receiving conventional therapy),group B (41 cases receiving conventional therapy + entecavir)and group C (47 cases receiving conventional therapy + entecavir and anti-fibrosis treatment ).The Fuzheng Huayu capsule was administrated for 24 weeks and all the patients were observed for 48 weeks.Results The liver cirrhosis-related parameters in Group C were more remarkably improved than that of Group A and Group B:HA( [ 152.3 ± 72.3 ]μg/L vs.[212.3 ± 86.9] μg/L,[325.6 ± 153.1 ] μg/L,F =30.18,P ＜ 0.01 ),LN( [ 104.7 ± 23.9 ] μg/L vs.[ 139.9 ±28.9] μg/L,[ 127.7 ±76.0] μg/L,F =36.99,P ＜0.01 ),Pc Ⅲ ( [ 167.8 ±61.4] μg/L vs.[207.5 ±78.1 ] μg/L,[ 263.1 ± 113.2 ] μg/L,F =30.34,P ＜ 0.01 ) and Child-Pugh scale ( [ 6.94 ± 1.31 ] vs.[ 7.53 ±1.24 ],[ 8.77 ± 1.36 ],F =14.45,P ＜ 0.01 ).The liver function-related parameters in Group C were significantly different from that of Group A and Group B:ALT( [58 ±41 ] U/L vs.[ 147 ±96] U/L,[75 ± 19]U/L,F =16.82,P ＜0.01 ),ALB( [38.1 ± 1.7]g/L vs.[26.5 ±3.5 ] g/L,[35.4 ± 1.8 ] g/L,F =4.69,P ＜0.01),TBil ([31.9 ± 12.7] μmol/L vs.[85.2 ±58.3] μmol/L,[46.1 ± 17.8] μmol/L,F.=15.10,P ＜0.01)and PTA improvement ([76 ±24]％ vs.[57 ± 12]％,[73 ± 18]％,F =79.26,P ＜0.01).Conclusion Entecavir can rapidly and effectively inhibit the replication of HBV in patients with decompensated hepatitis Bmediated cirrhosis and improve the liver function.When combined with fuzheng huayu capsule,entecavir will effectively improve the cirrhosis and elevate the serum albumin level.
