The change of α-melanocyte-stimulating hormone(α-MSH)in the serum of patients multipleinjuries
10.3760/cma.j.issn.1671-0282.2012.02.020
- VernacularTitle:多发创伤患者血清α-黑色素细胞刺激素的变化
- Author:
Qiang ZHOU
;
Guilong FENG
;
Jie FENG
;
Xiaoming YANG
;
Xiaodong DU
;
Yanfeng BIAN
- Publication Type:Journal Article
- Keywords:
Multiple trauma;
Alpha-melanocyte stimulating hormone;
Tumor necrosis factor-alpha;
Inflammatory
- From:
Chinese Journal of Emergency Medicine
2012;21(2):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the variations of the serum α-MSH and TNF-α in multiple-trauma patients and discuss their role in severity of casualties.Methods Fifty casualties were divided into two groups for study.There were 30 casualties with moderate severe trauma(ISS 16 ～ 25 point)and 20 patients with extreme severe trauma(ISS ＞ 25 point),and another 15 healthy subjects were enrolled as controls.The blood samples were obtained within 24 hours,and 3 days,5 days,7 days after admission.The serum levels of α-MSH and TNF-α in casualties with multiple injuries were determined by using enzyme-linked immunosorbent double antibody sandwich method(ELISA).The data were expressed in((x)± s),and analyzed with chi-square test and repetitive measures of ANOVA by using SPSS 13.0 package.P value less than 0.05 indicated statistical significance Results The serum α-MSH levels of casualties within 24 hours,and 3 days,5 days,7 days after injury in the two groups were much lower than those in the control group (P ＜ 0.01),while the serum TNF-α levels of casualties were much higher than those in the control group (P ＜0.01).The serum α-MSH levels of casualties with extreme severe traumawere lower,and the TNF-αlevels of casualties with extreme severe trauma were higher than those in patients with moderate severe trauma(P ＜0.01,respectively).There were negative correlations between two biomarkers 24 hours,5d and 7d after injury.Conclusions In casualties,the serum levels of α-MSH decreased and the serum levelsof TNF-α increased,and the degrees of changes were closely depended on the severity of trauma,the more severe the more significant changes.There was a negative correlation between two biomarkers.
