Correlation study between polymorphism of interleukin-1β genes and risk and pathological characteristics of gastric cancer in human
10.3760/cma.j.issn.1673 -4904.2012.05.006
- VernacularTitle:白细胞介素-1β基因多态性与人胃癌发病风险及病理特征的关系研究
- Author:
Weiqiang LAI
;
Xuefeng PAN
;
Chong JIN
;
Liming ZHANG
;
Chunling ZHANG
;
Yong ZHOU
;
Huilin ZHANG
- Publication Type:Journal Article
- Keywords:
Interleukin-1 beta;
Stomach neoplasms;
Polymorphism,genetic;
Pathological features
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(5):18-20
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the correlation between polymorphism of interleukin(IL)-1β genes and risk and pathological characteristics of gastric cancer in human.MethodsFrom January to December 2010,200 cases of gastric cancer(patient group) and 200 cases of chronic superficial gastritis (control group) were collected.DNA was extracted and IL-1β gene -511,-31,-1473,+3954 site were detected by gene chip technology.The correlation between IL-1β gene -511,-31,-1473,+3954 site and risk and pathological characteristic of gastric cancer was observed.ResultsThe genotype frequency of IL-1β gene -511,-31,-1473,+3954 site was 48.75％(195/400),55.25％(221/400),53.25％(213/400),50.75％ (203/400) in patient group,47.25％ (189/400),53.00％ (212/400),52.50％ (210/400),52.50％ (210/400) in control group,and there was significant difference between two groups (P ＜0.05).While IL-1β gene -511,-31 site T allelic with the lower degree of differentiation of gastric cancer,IL-1 β gene -511,-1473 site T allelic with the early age of gastric cancer.ConclusionsIL-1β gene -511,-31,-1473,+3954 site genotype increase the risk of gastric cancer.IL-1β gene -511,-31 site T allelic are related with the degree of differentiation of gastric cancer.IL-1β gene -511,-1473 site T allelic are related with age of gastric cancer patient.
