Clinical value of serum uric acid in patients with acute ST-elevation myocardial infarction
10.3760/cma.j.issn.1671-0282.2012.02.012
- VernacularTitle:血尿酸在急性ST段抬高心肌梗死患者的临床价值
- Author:
Li CHEN
;
Xianlun LI
;
Wei QIAO
;
Ying ZHOU
;
Yanli QIN
;
Yong WANG
;
Yujie ZENG
;
Yuannan KE
- Publication Type:Journal Article
- Keywords:
Acute ST-elevation myocardial infarction;
Serum uric acid;
Triglyceride;
Coronary angiography;
Echocardi-ography;
Left ventricular systolic function;
Left ventricular diastolic dysfunction;
Major adverse cardiovascular events
- From:
Chinese Journal of Emergency Medicine
2012;21(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical value of serum uric acid levels in patients with acute ST-elevation myocardial infarction(STEMI).Methods A total of 502 consecutive patients with STEMI were enrolled from January 2005 to December 2010 for retrospective study.The level of serum lipid,echocardiographic data and in-hospital major adverse cardiovascular events(MACE)in patients with hyperuricemia(n =119)were compared with those in patients without hyperuricemia(n =383).The relationship between the level of serum uric acid and the degree of diseased coronary artery was analyzed.All data were analyzed with SPSS version 17.0 software to make t test and x2 test and Pearson correlation analysis.Results Serum uric acid level was positively correlated with serum triglyceride level.Compared with non-hyperuricemia patients,hyperlipidemia was more commonly found among hyperuricemia patients (43.7％ vs.33.7％,P =0.047),and serum triglyceride level was significantly higher in hyperuricemia patients[(2.11 ± 1.24)mmol/L vs.(1.78 ± 1.38)mmol/L,P =0.014].But a significant association between serum uric acid level and one or more diseased vessels was not observed(P ≥ 0.05).Leftventricular end-diastolic diameter(LVEDd)was found to be larger in hyperuricemia patients than non-hyperuricemia patients[(53.52 ±6.19)mm vs.(52.18 ±4.89)mm,P =0.041].Higher incidence in left systolic dysfunction and diastolic dysfunction was discovered in hyperuricemia patients(36.4％ vs.15.1％,P ＜0.01; 68.2％ vs.55.8％,P =0.023).Also,hyp-eruricemia patients had more in-hospital MACE(P ＜ 0.05).Conclusions Serum uric acid level is positively correlated with serum triglyceride level,but not with the severity of coronary artery disease.Hyperuricemia patients after STEMI tended to have higher incidence in left systolic dysfunction and diastolic dysfunction,and have more in-hospital MACE.
