Evaluation of efficacy of acarbose by means of CGMS on blood glucose fluctuations during insulin therapy

VernacularTitle:采用CGMS评价阿卡波糖对胰岛素治疗血糖波动的影响
Author: Xiaojing LI ; Zhengnan GAO ; Lijing CHENG ; Min NIU ; Yonghang LI ; Guimei HOU ; Xuhan LIU
Publication Type:Journal Article
Keywords: Acarbose; Intensive insulin therapy; Diabetes mellitus,type 2; Continuous glucose monitoring system
From: Chinese Journal of Endocrinology and Metabolism 2012;28(2):140-143
CountryChina
Language:Chinese
Abstract: Sixty-two patients with type 2 diabetes were treated with acarbose combined intensive insulin therapy( combined intensive group)or intensive insulin therapy alone (simple intensive group).As the blood glucose control reached the target,the mean amplitude of glycaemic excursion (MAGE),the absolute difference between the mean of daily differences ( MODD ),and standard deviation of blood glucose (SDBG) in combined intensive group were lower than those in simple intensive group [ ( 3.76 ± 1.47 vs 6.52 ± 1.57 ) mmol/L,( 0.57 ±0.49 vs 1.10 ±0.69 )mmol/L,( 1.44±0.60 vs 2.42±0.92 ) mmol/L,all P＜0.01 ].Daily mean blood glucose (MBG) of the former group was better than that of the latter group [ (7.08±0.69 vs 8.27 ± 1.31 ) mmol/L,P＜0.01 ].By the end of treatment,HbA1c [ 6.77％ ± 0.57％ vs 7.21％ ±0.83％,P＜0.05 ],incidence of hypoglycemia( 29％ vs 48％,P＜0.01 ),and body mass index[ (24.14±2.7 vs 27.63±3.41 ) kg/m2,P＜0.01 ] in combined intensive group were statistically improved more than those in the simple intensive group.