Effect of hepatitis B immunoglobulin to prevent de novo hepatitis B infection after renal transplantation
10.3760/cma.j.issn.0254-1785.2012.02.010
- VernacularTitle:乙型肝炎免疫球蛋白预防肾移植后新发乙型肝炎
- Author:
Ning LI
;
Xiaotong WU
;
Mingjun WANG
;
Wenping GUO
;
Yuan DONG
;
Zuan FAN
;
Yuan NING
;
Tingting LIU
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Hepatitis B;
Immunoglobulins;
Precautions
- From:
Chinese Journal of Organ Transplantation
2012;33(2):105-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the safety and efficacy of low dose of hepatitis B immunoglobulin (HBIG) for prevention of de novo hepatitis B infection after renal transplantation.MethodsThe clinical data of 138 patients who received renal transplantation without hepatitis B infection between January 2007 and June 2010 were retrospectively studied (study group).All the patients in study group were given low dose of HBIG injection before transplantation.The HBsAb titer was monitored regularly after transplantation,and the dosage of HBIG adjusted according to the level of the HBsAb titer.HBIG was implied to all patients in the study group for more than one year.The clinical data of 196 patients who received renal transplantation without hepatitis B infection between January 2004 and December 2006 served as the control group.These 196 patients were not treated with HBIG.The incidence of de novo hepatitis B infection,and acute rejection of these two groups was analyzed.The one-year graft and patients survival rate was also investigated.Results During the follow- up period of 12 months,only one case in the study group had de novo hepatitis B infection (0.7％) 6 months after renal transplantation,while 11 cases (5.6％) in the control group had de novo hepatitis B infection,in which 2 cases were died from acute hepatic failure.The incidence of de novo hepatitis B infection had statistically difference between the two groups (P＜0.05).The incidence of acute rejection in the study and control groups was 13.8％ and 17.3％ respectively (P＞0.05).The one-year graft and patient survival rate in the study and control groups was 96.4％ and 97.8％,and 90.3％ and 91.8％ respectively (P＜0.05).ConclusionLow dose of HBIG is effective and safe for prevention of de novo hepatitis B infection after renal transplantation.
