Effects of anisodamine on neurological functional status of cerebral resuscitation: a systematic review and meta-analysis
10.3760/cma.j.issn.1671-0282.2012.01.007
- VernacularTitle:山莨菪碱对脑复苏神经功能影响的系统评价
- Author:
Jingming LIU
;
Yan WU
;
Yan LIU
;
Jing WANG
;
Kun WANG
;
Hua JING
- Publication Type:Journal Article
- Keywords:
Anisodamine;
Cerebral resuscitation;
Neurological function;
Systematic review;
Meta-analysis
- From:
Chinese Journal of Emergency Medicine
2012;21(1):28-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effects of Anisodamine on neurological function as well as the safety of using it after cerebral resuscitation. Methods The data of CNKI (from January 1979 through January 2011 ) and Pubmed (from January 1978 through January 2011 ) were searched.The Cochrane Library was applied for identifying randomized controlled trials (RCTs) about effects of Anisodamine on neurological function after cerebral resuscitation.The methodological quality was assessed and the data were collected according to the criteria defined in Cochrane Reviewer' s Handbook for meta-analyses with RevMan 5.0.25 package.Results Data of 327 patients from 4 eligible studies were included in this analysis.The results of meta-analyses showed that Anisodamine used after cerebral resuscitation improved Glasgow coma scale (GCS) in the early stage [ MD =1.4,95％ CI (0.98,1.82),P ＜0.01 ] and lessen neurological deficit (ND) in the later stage [ MD =-4.38,95％CI ( -5.26, -3.51 ),P ＜0.01 ].Meanwhile,the reduction of long-term ND of patients was documented in two studies ; the improvement of ability of daily life of patients in 2 ～ 3 months after anisodamine used was reported in two studies; the improvement of patients' quality of life (QL) was recorded in one study and the inhibited release of excitatory amino acid (EAA) was reported in one study.All eligible studies did not report any serious adverse effects of Anisodamine used after cerebral resuscitation. Conclusions Anisodamine used after cerebral resuscitation can improve patients'status of neurological function with relative safety of administration.
