Assessment of left ventricular diastolic function by brain natriuretic peptide and tissue doppler imaging in the elderly patients with diabetes mellitus and hypertension
10.3760/cma.j.issn.0254 9026.2012.02.010
- VernacularTitle:脑钠肽与超声心动图评价老年糖尿病并存高血压患者左心室舒张功能的研究
- Author:
Xiaoyun ZHENG
;
Duan QIAN
;
Xi WANG
;
Shaoxi YAN
;
Lei CHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Hypertension;
Ventricular dysfunction,left;
Natriuretic peptide,brain;
Echocardiography,doppler,pulsed
- From:
Chinese Journal of Geriatrics
2012;31(2):121-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between brain natriuretic peptide(BNP)and left ventricular diastolic function in the elderly patients with diabetes mellitus and hypertension.Methods 128 elderly patients with diabetes mellitus were divided into diabetes without hypertension (n=63)and with hypertension(n=65),and other 62 normal subjects were selected as control group.Plasma BNP levels and indexes of echocardiography,including left ventricular mass index(LVMI),the mitral peak flow velocity during early(E)and late diastole(A),ratio of E/A,average peak velocities at mitral annuluses of six sites in left ventricular wall during early(MEm)and late diastole (MAm),and relative E/MEm were measured in all patients.Results LVMI,E/MEm and the levels of BNP were significantly higher in groups of diabetes without and with hypertension[(91.6 ±17.3)g/m2 and(116.7±20.5)g/m2,(10.3±1.8)and(12.5±1.4),(47.7±29.4)ng/L and(105.7±32.5)ng/L]than in control group[(78.7±19.5)g/m2,(8.9± 1.6)and(20.8±11.63)ng/L,respectively](F=11.54,13.83 and 9.75,all P＜0.05),while MEm in two diabetes groups[(6.8±1.0)and(5.4±0.9)cm/s]were decreased as compared with control group[(8.0± 1.1)cm/s,F=11.26,P＜0.05].The BNP levels were negatively correlated with E/A and MEm(r =-0.42 and -0.51,all P＜0.01),and positively correlated with LVMI and E/MEm(r=0.48 and 0.58,all P＜0.01).Conclusions Left ventricular diastolic function is impaired in diabetes mellitus and more severely impaired in diabetic patients with hypertension.A combination of plasma BNP and echocardiography parameter may be helpful to accurately evaluate left ventricular diastolic function in the elderly patients with diabetes mellitus and hypertension.
